Periventricular Leukomalacia

Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)

Also Known As:

Neonatal Cerebral Leukomalacia; Leukomalacia, Periventricular; Leucomalacia, Periventricular; Cerebral Leukomalacia, Neonatal; Cerebral Leukomalacias, Neonatal; Cystic Periventricular Leukomalacias; Encephalomalacias, Periventricular; Leucomalacias, Periventricular; Leukomalacia, Cystic Periventricular; Leukomalacia, Neonatal Cerebral; Leukomalacias, Cystic Periventricular; Leukomalacias, Neonatal Cerebral; Leukomalacias, Periventricular; Neonatal Cerebral Leukomalacias; Periventricular Encephalomalacia; Periventricular Encephalomalacias; Periventricular Leucomalacia; Periventricular Leucomalacias; Periventricular Leukomalacia, Cystic; Periventricular Leukomalacias; Periventricular Leukomalacias, Cystic; Cystic Periventricular Leukomalacia; Encephalomalacia, Periventricular

Nervous System Diseases: 14737
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Cerebrovascular Disorders: 7764
      - Periventricular Leukomalacia: 555
    - Encephalomalacia: 140
      - Periventricular Leukomalacia: 555
Cardiovascular Diseases: 94258
- Vascular Diseases: 15340
  - Cerebrovascular Disorders: 7764
    - Periventricular Leukomalacia: 555
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Diseases Newborn Infant: 271
  - Diseases Premature Infant: 1
    - Periventricular Leukomalacia: 555

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